Su madre murió cuando era joven, y su abuela lo crio.

English

His mother died when he was young, and his grandmother brought him up.

“Su madre murió cuando era joven”, I find this ambiguous but leaning towards the mother being young. Personal pronouns have their uses.

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If the mother died young maybe “Su madre murió joven” would have been more succinct, but apart from that I still think the sentence is ambiguous.

Su madre murió cuando (él) era joven y ( por lo tanto) su abuela lo crió (a él).

Su madre no murió joven, quien era joven era el hijo. La frase es correcta.

Hope this helps.

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Can I infer that su is enough to put the focus on the boy rather than the mother?

See also: Su caballo le dio una coz en la cabeza y murió.

I don’t think so, because this phrase also has a similar meaning, although it is generic and does not begin with ‘Su’:

El/un caballo le dio una coz y murió.

Hope this helps.