Tiene amigos en medio mundo gracias a su trabajo.

English Translation

He has friends all over the world thanks to his job.

The RAE doesn’t have an entry on “en medio mundo”, only this:

medio mundo

m. coloq. Una cantidad grande de gente. Medio mundo estaba allí.

https://dle.rae.es/mundo#9oppqmK

Maybe it’s just not considered a fixed expression; it does sound perfectly fine nonetheless

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