Que sepamos, los humanos estamos solos en el universo.

English Translation

As far as we know, we humans are alone in the universe.

First time I’ve ever seen a first person plural verb conjugation where the subject isn’t “nosotros”. Does this sound natural to spanish speakers?

It is natural. I guess some words like Humans refers to us all, and doesn’t need the subject to be present in the sentence.

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