Тому-то и непонятно.

English Translation

Tom is the one who doesn’t understand.

The expression “Тому-то и непонятно” is a little idiomatic, so it helps to break it down.

тому — “to that person” / “for that person”
-то — an emphatic particle (“that’s exactly…”)
и — here means something like “that’s precisely why” or “indeed”
непонятно — “it is unclear,” “it doesn’t make sense”

So the overall meaning is:

“That’s exactly what they don’t understand.”
“That’s precisely what’s unclear to them.”
“That’s the very thing they don’t understand.”
“That’s why they’re confused.” (depending on context)

For example:

— Почему он не пришёл?
— Тому-то и непонятно.

Literally:

“Why didn’t he come?”
“That’s exactly what isn’t understood.”

Natural English:

“That’s the mystery.”
“That’s exactly what nobody understands.”
“That’s what we’re trying to figure out.”

The combination X-то и Y is quite common in Russian and often has the sense of “that’s exactly the point”:

Вот-то и дело. — “That’s exactly the point.”
В том-то и проблема. — “That’s exactly the problem.”
В том-то и беда. — “That’s the trouble.”
Тому-то и непонятно. — “That’s exactly what they don’t understand.”

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That’s very helpful. Thanks!