Sie vernachlässigt ihr Äußeres.

That is a strange use of ‘regardless’ that I can’t find in the dictionary (but I’m not a native speaker).

Can you please cite the official English translation?

I would translate
“She neglects her looks.”
(but I am also not a native English speaker).

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“She is regardless of her appearance.”

Source: Sie vernachlässigt ihr Äußeres. - German example sentence - Tatoeba