Er legte sein Amt wegen einer Krankheit nieder.

I don’t see how nieder fits into this sentence.

niederlegen is a separable verb which means to resign from something.

So the whole sentence in English would be: He resigned from office because of illness.

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Vielen Dank! I’m still getting tricked by separable verbs, to the point of posting when I find a particularly tricky one.

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